Peter Myler, PhD

The Myler laboratory makes extensive use of genome-scale approaches, such as for genome (re-)sequencing, mRNA profiling (RNA-seq) and chromatin immunoprecipitation using sequencing (ChIP-seq), to investigate the molecular mechanisms underlying transcription and regulation of gene expression during Leishmania differentiation. We are particularly interested in elucidating the role of epigenomic histone and DNA modifications (including the novel DNA base J) in these processes. For the past 20 years, we have been actively involved in structural genomics and Dr. Myler is currently PI and director of the Seattle Structural Genomics Center for Infectious Disease (SSGCID), which is funded under a contract from the National Institute of Allergy and Infectious Diseases (NIAID). The mission of SSGCID is to use X-ray crystallography, Cryo-electron microscopy and NMR spectroscopy to solve the structure of proteins targets in emerging and re-emerging infectious disease organisms, primarily to facilitate development of new therapeutics using structure-based drug design.